BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Histone deacetylase (HDAC1 and HDAC2)' and Ligand = 'BDBM50498499'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histone deacetylase (HDAC1 and HDAC2)


(Homo sapiens (Human))		BDBM50498499
PNG
(CHEMBL3605904)
Show SMILES ONC(=O)c1ccc(CN2C(=O)c3ccc(NC(=O)c4ccc(cc4)C(F)(F)F)cc3S2(=O)=O)cc1
Show InChI InChI=1S/C23H16F3N3O6S/c24-23(25,26)16-7-5-14(6-8-16)20(30)27-17-9-10-18-19(11-17)36(34,35)29(22(18)32)12-13-1-3-15(4-2-13)21(31)28-33/h1-11,33H,12H2,(H,27,30)(H,28,31)
PDB

UniProtKB/SwissProt

DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.41E+3n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of HDAC1/2 in human HeLa cells nuclear extracts using acetylated histone peptide as substrate after 30 mins by Color de Lys assay

Bioorg Med Chem 23: 5774-81 (2015)


Article DOI: 10.1016/j.bmc.2015.07.008
BindingDB Entry DOI: 10.7270/Q2CZ3B56
More data for this
Ligand-Target Pair