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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Histone deacetylase 11 (Homo sapiens (Human)) | BDBM50380399 (CHEMBL2018302 | Tubastatin A | US10227295, Compoun...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet  | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | >30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. | Citation and Details BindingDB Entry DOI: 10.7270/Q2639SXJ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histone deacetylase 11 (Homo sapiens (Human)) | BDBM50380399 (CHEMBL2018302 | Tubastatin A | US10227295, Compoun...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | 3.79E+3 | n/a | n/a | n/a | n/a | 8.0 | n/a |
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS; THE CHILDREN'S HOSPITAL OF PHILADELPHIA US Patent | Assay Description HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC... | US Patent US9249087 (2016) BindingDB Entry DOI: 10.7270/Q2Q23Z3W | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histone deacetylase 11 (Homo sapiens (Human)) | BDBM50380399 (CHEMBL2018302 | Tubastatin A | US10227295, Compoun...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1016/j.bmc.2022.117028 BindingDB Entry DOI: 10.7270/Q20869DR | ||||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histone deacetylase 11 (Homo sapiens (Human)) | BDBM50380399 (CHEMBL2018302 | Tubastatin A | US10227295, Compoun...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of recombinant human HDAC11 measured after 30 mins by fluorescence microplate reader assay | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01311 BindingDB Entry DOI: 10.7270/Q2MP574P | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histone deacetylase 11 (Homo sapiens (Human)) | BDBM50380399 (CHEMBL2018302 | Tubastatin A | US10227295, Compoun...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | n/a | n/a | 8.78E+3 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Assay Description Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria | Citation and Details | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histone deacetylase 11 (Homo sapiens (Human)) | BDBM50380399 (CHEMBL2018302 | Tubastatin A | US10227295, Compoun...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 1.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human full length recombinant HDAC11 using p53 (379 to 382 residues) (RHKK(Ac)AMC) as substrate preincubated for 5 to 10 mins followed ... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00830 BindingDB Entry DOI: 10.7270/Q2F76H9K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histone deacetylase 11 (Homo sapiens (Human)) | BDBM50380399 (CHEMBL2018302 | Tubastatin A | US10227295, Compoun...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | 1.97E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS US Patent | Assay Description The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I... | US Patent US10456394 (2019) BindingDB Entry DOI: 10.7270/Q2Q81GFW | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histone deacetylase 11 (Homo sapiens (Human)) | BDBM50380399 (CHEMBL2018302 | Tubastatin A | US10227295, Compoun...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histone deacetylase 11 (Homo sapiens (Human)) | BDBM50380399 (CHEMBL2018302 | Tubastatin A | US10227295, Compoun...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
"G. D'Annunzio" University of Chieti-Pescara Curated by ChEMBL | Assay Description Inhibition of HDAC11 (unknown origin) using Boc-Lys(acetyl)-AMC as substrate after 30 mins by fluorescence assay | Eur J Med Chem 143: 1543-1552 (2018) Article DOI: 10.1016/j.ejmech.2017.10.022 BindingDB Entry DOI: 10.7270/Q2028V2K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histone deacetylase 11 (Homo sapiens (Human)) | BDBM50380399 (CHEMBL2018302 | Tubastatin A | US10227295, Compoun...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
SynBioC Research Group, Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium. Curated by ChEMBL | Assay Description Inhibition of N-terminal GST-tagged human HDAC11 expressed in baculovirus expression systemRHKAcKAc after 2 hrs by fluorescence assay | Eur J Med Chem 135: 174-195 (2017) Article DOI: 10.1016/j.ejmech.2017.04.013 BindingDB Entry DOI: 10.7270/Q2G44SQS | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histone deacetylase 11 (Homo sapiens (Human)) | BDBM50380399 (CHEMBL2018302 | Tubastatin A | US10227295, Compoun...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of HDAC11 (unknown origin) | Citation and Details Article DOI: 10.1016/j.ejmech.2021.113526 BindingDB Entry DOI: 10.7270/Q2D79G8J | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histone deacetylase 11 (Homo sapiens (Human)) | BDBM50380399 (CHEMBL2018302 | Tubastatin A | US10227295, Compoun...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01782 BindingDB Entry DOI: 10.7270/Q2G73JP3 | ||||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histone deacetylase 11 (Homo sapiens (Human)) | BDBM50380399 (CHEMBL2018302 | Tubastatin A | US10227295, Compoun...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of full length N-terminal GST-tagged human HDAC11 using Arg-His-Lys-Lys(Ac) substrate incubated for 2 hrs by fluorescence assay | Bioorg Med Chem Lett 24: 5450-4 (2015) Article DOI: 10.1016/j.bmcl.2014.10.022 BindingDB Entry DOI: 10.7270/Q2B859QH | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histone deacetylase 11 (Homo sapiens (Human)) | BDBM50380399 (CHEMBL2018302 | Tubastatin A | US10227295, Compoun...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | 8.0 | 25 |
The Board of Trustees of The University of Illinois US Patent | Assay Description HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC... | US Patent US8748451 (2014) BindingDB Entry DOI: 10.7270/Q26D5RPK | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
