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Found 1 hit Enz. Inhib. hit(s) with Target = 'Histone lysine demethylase PHF8' and Ligand = 'BDBM276069'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histone lysine demethylase PHF8


(Homo sapiens (Human))		BDBM276069
PNG
(4-(1H-triazol-4-yl)-2-[1-[2-[2-(trifluoromethyl)ph...)
Show SMILES FC(F)(F)c1ccccc1CCn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
Show InChI InChI=1S/C19H15F3N6/c20-19(21,22)15-4-2-1-3-13(15)6-8-28-11-18(24-12-28)16-9-14(5-7-23-16)17-10-25-27-26-17/h1-5,7,9-12H,6,8H2,(H,25,26,27)
PDB

UniProtKB/SwissProt

antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/an/an/a



GSK



Assay Description
PHF8 Assay: The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction condit...

Bioorg Med Chem Lett 17: 1584-9 (2007)


BindingDB Entry DOI: 10.7270/Q2FT8PBQ
More data for this
Ligand-Target Pair