Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histone-arginine methyltransferase CARM1 (Mus musculus (mouse)) | BDBM27659 (1-(3-{[(2S)-2-aminopropanamido]methyl}phenyl)-N-be...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 80 | n/a | n/a | n/a | n/a | 9.0 | 22 |
MethylGene Inc. | Assay Description Histone H3 is used as the substrate for CARM-1 enzyme, and the methylation is monitored using tritiated S-Adenosyl-Methionine (SAM) as a methyl donor... | Bioorg Med Chem Lett 19: 1218-23 (2009) Article DOI: 10.1016/j.bmcl.2008.12.075 BindingDB Entry DOI: 10.7270/Q2K64GC6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-arginine methyltransferase CARM1 (Homo sapiens (Human)) | BDBM27659 (1-(3-{[(2S)-2-aminopropanamido]methyl}phenyl)-N-be...) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research and Development Curated by ChEMBL | Assay Description Inhibition of human GST-tagged CARM1 by methylation assay | Bioorg Med Chem Lett 18: 4438-41 (2008) Article DOI: 10.1016/j.bmcl.2008.06.026 BindingDB Entry DOI: 10.7270/Q2KP832Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-arginine methyltransferase CARM1 (Homo sapiens (Human)) | BDBM27659 (1-(3-{[(2S)-2-aminopropanamido]methyl}phenyl)-N-be...) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research and Development Curated by ChEMBL | Assay Description Inhibition of CARM1 assessed as blockade of histone H3 methylation | Bioorg Med Chem Lett 19: 2924-7 (2009) Article DOI: 10.1016/j.bmcl.2009.04.075 BindingDB Entry DOI: 10.7270/Q24B3170 | |||||||||||
More data for this Ligand-Target Pair |