Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM291686 (8-(1,3-Dimethyl-1H-pyrazol-5-yl)-N-((5-fluoro-2,3-...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale... | US Patent US9580437 (2017) BindingDB Entry DOI: 10.7270/Q24T6MD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM291686 (8-(1,3-Dimethyl-1H-pyrazol-5-yl)-N-((5-fluoro-2,3-...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.10 | n/a | n/a | n/a | n/a | 8.0 | n/a |
Novartis AG US Patent | Assay Description To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw... | US Patent US9580437 (2017) BindingDB Entry DOI: 10.7270/Q24T6MD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM291686 (8-(1,3-Dimethyl-1H-pyrazol-5-yl)-N-((5-fluoro-2,3-...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 8.20 | n/a | n/a | n/a | n/a | 8.0 | n/a |
Novartis AG US Patent | Assay Description Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra... | US Patent US9580437 (2017) BindingDB Entry DOI: 10.7270/Q24T6MD7 | |||||||||||
More data for this Ligand-Target Pair |