Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Histone-lysine N-methyltransferase EZH2' and Ligand = 'BDBM227711'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM227711 (US9556157, 2 | n-((2,6-dimethyl-4-oxo-1,4-dihydrop...) Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)[nH]c(C)cc2=O)c1C |r,wU:6.9,wD:3.2,(4.82,-1.84,;3.73,-2.93,;2.25,-2.53,;1.16,-3.62,;-.33,-3.22,;-1.42,-4.31,;-1.02,-5.8,;.47,-6.2,;1.55,-5.11,;-2.11,-6.89,;-3.6,-6.49,;-1.71,-8.38,;1.85,-1.05,;.38,-.57,;.38,.97,;1.85,1.45,;1.85,2.99,;3.18,3.76,;.51,3.76,;.51,5.3,;-.82,6.07,;-.82,7.61,;.51,8.38,;-2.15,8.38,;-3.49,7.61,;-4.82,8.38,;-3.49,6.07,;-2.15,5.3,;-2.15,3.76,;2.75,.2,;4.24,.6,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	32	n/a	n/a	n/a	n/a	8.0	25
GlaxoSmithKline Intellectual Property (No.2) Limited US Patent					Assay Description Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...				US Patent US9556157 (2017) BindingDB Entry DOI: 10.7270/Q2MP558N
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM227711 (US9556157, 2 | n-((2,6-dimethyl-4-oxo-1,4-dihydrop...) Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)[nH]c(C)cc2=O)c1C |r,wU:6.9,wD:3.2,(4.82,-1.84,;3.73,-2.93,;2.25,-2.53,;1.16,-3.62,;-.33,-3.22,;-1.42,-4.31,;-1.02,-5.8,;.47,-6.2,;1.55,-5.11,;-2.11,-6.89,;-3.6,-6.49,;-1.71,-8.38,;1.85,-1.05,;.38,-.57,;.38,.97,;1.85,1.45,;1.85,2.99,;3.18,3.76,;.51,3.76,;.51,5.3,;-.82,6.07,;-.82,7.61,;.51,8.38,;-2.15,8.38,;-3.49,7.61,;-4.82,8.38,;-3.49,6.07,;-2.15,5.3,;-2.15,3.76,;2.75,.2,;4.24,.6,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	100	n/a	n/a	n/a	n/a	8.0	25
GlaxoSmithKline Intellectual Property (No.2) Limited US Patent					Assay Description Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...				US Patent US9556157 (2017) BindingDB Entry DOI: 10.7270/Q2MP558N
					More data for this Ligand-Target Pair