Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Histone-lysine N-methyltransferase EZH2' and Ligand = 'BDBM326119'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM326119 (US10273223, Compound D-17 | US9637472, Compound D-...) Show SMILES CN(C)Cc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(Br)cc2n(ncc12)C1CCCC1 Show InChI InChI=1S/C23H28BrN5O2/c1-14-8-15(13-28(2)3)19(23(31)27-14)11-25-22(30)18-9-16(24)10-21-20(18)12-26-29(21)17-6-4-5-7-17/h8-10,12,17H,4-7,11,13H2,1-3H3,(H,25,30)(H,27,31)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<300	n/a	n/a	n/a	n/a	n/a	n/a
IRBM/Merck					Assay Description eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....				J Med Chem 51: 2350-3 (2008) BindingDB Entry DOI: 10.7270/Q28P62V9
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM326119 (US10273223, Compound D-17 | US9637472, Compound D-...) Show SMILES CN(C)Cc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(Br)cc2n(ncc12)C1CCCC1 Show InChI InChI=1S/C23H28BrN5O2/c1-14-8-15(13-28(2)3)19(23(31)27-14)11-25-22(30)18-9-16(24)10-21-20(18)12-26-29(21)17-6-4-5-7-17/h8-10,12,17H,4-7,11,13H2,1-3H3,(H,25,30)(H,27,31)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<300	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...				US Patent US9637472 (2017) BindingDB Entry DOI: 10.7270/Q2X0693B
					More data for this Ligand-Target Pair