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Found 1 hit Enz. Inhib. hit(s) with Target = 'Histone-lysine N-methyltransferase EZH2' and Ligand = 'BDBM50063681'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))		BDBM50063681
PNG
(CHEMBL3397318)
Show SMILES N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(=O)NCc1ccccc1 |r|
Show InChI InChI=1S/C21H27N7O4S/c22-13(20(31)24-8-12-4-2-1-3-5-12)6-7-33-9-14-16(29)17(30)21(32-14)28-11-27-15-18(23)25-10-26-19(15)28/h1-5,10-11,13-14,16-17,21,29-30H,6-9,22H2,(H,24,31)(H2,23,25,26)/t13-,14+,16+,17+,21+/m0/s1
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PC cid
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Similars
Article
PubMed
n/an/a 1.20E+5n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminally FLAG-tagged wild type EZH2 in EZH2/SUZ12/EED/RbAp48 complex (unknown origin) expressed in baculovirus infected in SF9 cell...

Bioorg Med Chem Lett 25: 1532-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.017
BindingDB Entry DOI: 10.7270/Q2TM7CSS
More data for this
Ligand-Target Pair