Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Histone-lysine N-methyltransferase EZH2 [A687V]' and Ligand = 'BDBM172168'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone-lysine N-methyltransferase EZH2 [A687V] (Homo sapiens (Human))	BDBM172168 (EPZ008495 | US10155002, Compound 176 | US11052093,...) Show SMILES CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc(N(CC)C2CCOCC2)c1C)-c1ccc(CN2CCOCC2)cc1 Show InChI InChI=1S/C36H48N4O4/c1-5-7-29-20-25(3)38-36(42)33(29)23-37-35(41)32-21-30(22-34(26(32)4)40(6-2)31-12-16-43-17-13-31)28-10-8-27(9-11-28)24-39-14-18-44-19-15-39/h8-11,20-22,31H,5-7,12-19,23-24H2,1-4H3,(H,37,41)(H,38,42)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.40	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description Test compounds were serially diluted 3-fold in DMSO in a 10 point-curve and 1 uL was spotted into a 384-well microplate in duplicate using a Platemat...				US Patent US9175331 (2015) BindingDB Entry DOI: 10.7270/Q2ZW1JQP
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