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Found 1 hit Enz. Inhib. hit(s) with Target = 'Hormone-sensitive lipase' and Ligand = 'BDBM50233408'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Hormone-sensitive lipase


(Homo sapiens (Human))		BDBM50233408
PNG
(CHEMBL4090644)
Show SMILES CN(c1ccc(OC(F)(F)F)cc1)c1ccc(cn1)C(=O)Nc1ccccc1B1OC(C)(C)C(C)(C)O1
Show InChI InChI=1S/C26H27BF3N3O4/c1-24(2)25(3,4)37-27(36-24)20-8-6-7-9-21(20)32-23(34)17-10-15-22(31-16-17)33(5)18-11-13-19(14-12-18)35-26(28,29)30/h6-16H,1-5H3,(H,32,34)
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n/an/a 40n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human HSL expressed in baculovirus infected sf9 cells using PNPB as substrate after 5 mins by spectrophotometric method

Bioorg Med Chem 25: 2234-2243 (2017)


Article DOI: 10.1016/j.bmc.2017.02.045
BindingDB Entry DOI: 10.7270/Q2VH5R3W
More data for this
Ligand-Target Pair