Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Hypoxia-inducible factor 1-alpha' and Ligand = 'BDBM50354127'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM50354127 (CHEMBL1836177) Show SMILES COc1ccccc1-n1c(CN2CCN(CC2)C(=O)c2ccco2)nc2ccccc2c1=O |(4.66,1.69,;3.33,2.46,;3.33,4,;4.67,4.77,;4.67,6.31,;3.34,7.08,;2,6.31,;2,4.77,;.67,4.01,;.66,2.47,;2,1.69,;1.99,.15,;.66,-.61,;.65,-2.15,;1.99,-2.93,;3.32,-2.16,;3.32,-.62,;1.98,-4.47,;3.32,-5.24,;.65,-5.23,;-.76,-4.6,;-1.79,-5.75,;-1.02,-7.08,;.48,-6.76,;-.67,1.7,;-2,2.47,;-3.34,1.7,;-4.67,2.48,;-4.67,4.02,;-3.33,4.78,;-2,4.01,;-.67,4.78,;-.66,6.32,)| Show InChI InChI=1S/C25H24N4O4/c1-32-21-10-5-4-9-20(21)29-23(26-19-8-3-2-7-18(19)24(29)30)17-27-12-14-28(15-13-27)25(31)22-11-6-16-33-22/h2-11,16H,12-15,17H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
National Human Genome Research Institute Curated by ChEMBL					Assay Description Inhibition of hypoxia-induced HIF1alpha activation in human ME180 cells by HRE3-Bla-luciferase reporter gene assay				Bioorg Med Chem Lett 21: 5239-43 (2011) Article DOI: 10.1016/j.bmcl.2011.07.043 BindingDB Entry DOI: 10.7270/Q2H70G65
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