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Found 1 hit Enz. Inhib. hit(s) with Target = 'Ileal sodium/bile acid cotransporter' and Ligand = 'BDBM50434832'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Ileal sodium/bile acid cotransporter


(Homo sapiens (Human))		BDBM50434832
PNG
(CHEMBL2387516)
Show SMILES CCCC[C@]1(CC)CS(=O)(=O)c2cc(OCP(O)(O)=O)c(OC)cc2[C@H](N1)c1ccccc1 |r|
Show InChI InChI=1S/C23H32NO7PS/c1-4-6-12-23(5-2)15-33(28,29)21-14-20(31-16-32(25,26)27)19(30-3)13-18(21)22(24-23)17-10-8-7-9-11-17/h7-11,13-14,22,24H,4-6,12,15-16H2,1-3H3,(H2,25,26,27)/t22-,23-/m1/s1
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Similars
Article
PubMed
n/an/a 900n/an/an/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human ASBT expressed in HEK293 cells assessed as inhibition of [3H]-taurocholate uptake after 90 mins by scintillation counting analysi...

J Med Chem 56: 5094-114 (2013)


Article DOI: 10.1021/jm400459m
BindingDB Entry DOI: 10.7270/Q2MC91D6
More data for this
Ligand-Target Pair