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Found 1 hit Enz. Inhib. hit(s) with Target = 'Ileal sodium/bile acid cotransporter' and Ligand = 'BDBM50434841'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Ileal sodium/bile acid cotransporter


(Homo sapiens (Human))		BDBM50434841
PNG
(CHEMBL2387414)
Show SMILES CCCC[C@]1(CC)CS(=O)(=O)c2cc(CNC(C)(C)C(O)=O)c(OC)cc2[C@H](N1)c1ccccc1 |r|
Show InChI InChI=1S/C27H38N2O5S/c1-6-8-14-27(7-2)18-35(32,33)23-15-20(17-28-26(3,4)25(30)31)22(34-5)16-21(23)24(29-27)19-12-10-9-11-13-19/h9-13,15-16,24,28-29H,6-8,14,17-18H2,1-5H3,(H,30,31)/t24-,27-/m1/s1
KEGG

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PC sid
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Similars
Article
PubMed
n/an/a 190n/an/an/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human ASBT expressed in HEK293 cells assessed as inhibition of [3H]-taurocholate uptake after 90 mins by scintillation counting analysi...

J Med Chem 56: 5094-114 (2013)


Article DOI: 10.1021/jm400459m
BindingDB Entry DOI: 10.7270/Q2MC91D6
More data for this
Ligand-Target Pair