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Found 1 hit Enz. Inhib. hit(s) with Target = 'Ileal sodium/bile acid cotransporter' and Ligand = 'BDBM50434845'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Ileal sodium/bile acid cotransporter


(Homo sapiens (Human))		BDBM50434845
PNG
(CHEMBL2387515)
Show SMILES CCCC[C@]1(CC)CS(=O)(=O)c2cc(C(=O)NC(CC(O)=O)CC(O)=O)c(OC)cc2[C@H](N1)c1ccccc1 |r|
Show InChI InChI=1S/C28H36N2O8S/c1-4-6-12-28(5-2)17-39(36,37)23-16-20(27(35)29-19(13-24(31)32)14-25(33)34)22(38-3)15-21(23)26(30-28)18-10-8-7-9-11-18/h7-11,15-16,19,26,30H,4-6,12-14,17H2,1-3H3,(H,29,35)(H,31,32)(H,33,34)/t26-,28-/m1/s1
KEGG

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PC sid
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Similars
Article
PubMed
n/an/a 97n/an/an/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human ASBT expressed in HEK293 cells assessed as inhibition of [3H]-taurocholate uptake after 90 mins by scintillation counting analysi...

J Med Chem 56: 5094-114 (2013)


Article DOI: 10.1021/jm400459m
BindingDB Entry DOI: 10.7270/Q2MC91D6
More data for this
Ligand-Target Pair