BindingDB PrimarySearch

Found 5 hits Enz. Inhib. hit(s) with Target = 'Indoleamine 2,3-dioxygenase 1' and Ligand = 'BDBM50240612'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM50240612 (CHEMBL306946 \| GNF-PF-2691 \| Indolo[2,1-b]quinazol...) Show SMILES O=C1c2ccccc2-n2c1nc1ccccc1c2=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	4.81E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Fudan University Curated by ChEMBL					Assay Description Mixed competitive inhibition of human recombinant IDO1 using L-tryptophan as substrate				J Med Chem 56: 8321-31 (2013) Article DOI: 10.1021/jm401195n BindingDB Entry DOI: 10.7270/Q2X34ZWS
Fudan University Curated by ChEMBL					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM50240612 (CHEMBL306946 \| GNF-PF-2691 \| Indolo[2,1-b]quinazol...) Show SMILES O=C1c2ccccc2-n2c1nc1ccccc1c2=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	54	n/a	n/a	n/a	n/a	n/a	n/a
Fudan University Curated by ChEMBL					Assay Description Inhibition of human IDO1 expressed in HEK293 cells assessed as kynurenine release after 5 hrs by spectrophotometry				J Med Chem 56: 8321-31 (2013) Article DOI: 10.1021/jm401195n BindingDB Entry DOI: 10.7270/Q2X34ZWS
Fudan University Curated by ChEMBL					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM50240612 (CHEMBL306946 \| GNF-PF-2691 \| Indolo[2,1-b]quinazol...) Show SMILES O=C1c2ccccc2-n2c1nc1ccccc1c2=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Peking University US Patent					Assay Description Experimental method: IDO-1 can oxidatively cleave the indole ring of tryptophan to form N-formylkynurenine. Referring to the method in the literature...				US Patent US10669273 (2020) BindingDB Entry DOI: 10.7270/Q2GQ71SK
Peking University US Patent					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM50240612 (CHEMBL306946 \| GNF-PF-2691 \| Indolo[2,1-b]quinazol...) Show SMILES O=C1c2ccccc2-n2c1nc1ccccc1c2=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7.15E+3	n/a	n/a	n/a	n/a	n/a	n/a
Fudan University Curated by ChEMBL					Assay Description Mixed competitive inhibition of human recombinant IDO1 using L-tryptophan as substrate				J Med Chem 56: 8321-31 (2013) Article DOI: 10.1021/jm401195n BindingDB Entry DOI: 10.7270/Q2X34ZWS
Fudan University Curated by ChEMBL					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM50240612 (CHEMBL306946 \| GNF-PF-2691 \| Indolo[2,1-b]quinazol...) Show SMILES O=C1c2ccccc2-n2c1nc1ccccc1c2=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.99E+5	n/a	n/a	n/a	n/a	n/a	n/a
Indo-Soviet Friendship College of Pharmacy (ISFCP) Curated by ChEMBL					Assay Description Inhibition of human cytomegalovirus DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes at 26 d...				Bioorg Med Chem 25: 4533-4552 (2017) Article DOI: 10.1016/j.bmc.2017.07.003 BindingDB Entry DOI: 10.7270/Q2125W42
					More data for this Ligand-Target Pair