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Found 1 hit Enz. Inhib. hit(s) with Target = 'Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]' and Ligand = 'BDBM470958'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]


(Homo sapiens (Human))		BDBM470958
PNG
((1S,3'R,6'R,7'R,8'E,11'S,12'R)- 6-chloro-7'-(((3R,...)
Show SMILES CCN1[C@@H](C)CN(C[C@@]2(OC)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c3ccc4OC[C@]5(CCCc6cc(Cl)ccc56)CN(C[C@@H]5CC[C@@H]25)c4c3)C[C@H]1C |r,t:11|
Show InChI InChI=1S/C42H59ClN4O5S/c1-7-47-29(3)22-45(23-30(47)4)26-42(51-6)19-8-10-28(2)31(5)53(49,50)44-40(48)33-13-17-39-38(21-33)46(24-34-12-15-37(34)42)25-41(27-52-39)18-9-11-32-20-35(43)14-16-36(32)41/h8,13-14,16-17,19-21,28-31,34,37H,7,9-12,15,18,22-27H2,1-6H3,(H,44,48)/b19-8+/t28-,29-,30+,31+,34-,37+,41-,42-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0520n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...

US Patent US10821115 (2020)


BindingDB Entry DOI: 10.7270/Q23T9MB5
More data for this
Ligand-Target Pair