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Found 1 hit Enz. Inhib. hit(s) with Target = 'Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]' and Ligand = 'BDBM471450'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]


(Homo sapiens (Human))		BDBM471450
PNG
(US10821115, Example 100466 | US11224601, Example 1...)
Show SMILES COCCO[C@@]1(C)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:7|
Show InChI InChI=1S/C36H47ClN2O6S/c1-24-7-5-15-35(3,45-18-17-43-4)30-12-9-28(30)21-39-22-36(16-6-8-26-19-29(37)11-13-31(26)36)23-44-33-14-10-27(20-32(33)39)34(40)38-46(41,42)25(24)2/h5,10-11,13-15,19-20,24-25,28,30H,6-9,12,16-18,21-23H2,1-4H3,(H,38,40)/b15-5+/t24-,25+,28-,30+,35-,36-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0430n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...

US Patent US10821115 (2020)


BindingDB Entry DOI: 10.7270/Q23T9MB5
More data for this
Ligand-Target Pair