Found 2 hits Enz. Inhib. hit(s) with Target = 'Insulin-like growth factor 1 receptor' and Ligand = 'BDBM50156375' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50156375
(CHEMBL3785995)Show SMILES Nc1ncnc2n(cc(-c3ccc(F)c(OCC45CCC(CC4)O5)c3)c12)[C@@H]1C[C@H](CN2CC[S+]([O-])CC2)C1 |r,wD:26.30,28.33,(-1.03,2.79,;-1.03,1.55,;-2.38,.77,;-2.38,-.77,;-1.03,-1.55,;.3,-.77,;1.76,-1.24,;2.66,.02,;1.76,1.24,;2.23,2.7,;3.76,2.91,;4.33,4.34,;3.38,5.56,;3.84,6.7,;1.86,5.34,;.91,6.55,;-.62,6.33,;-1.57,7.54,;-2.89,6.94,;-3.98,7.99,;-3.62,9.48,;-2.14,9.89,;-1.05,8.84,;-2.2,8.68,;1.29,3.91,;.3,.77,;2.24,-2.7,;3.54,-3.45,;2.74,-4.76,;3.1,-6.25,;4.58,-6.69,;4.94,-8.18,;6.42,-8.61,;7.53,-7.55,;8.72,-7.9,;7.17,-6.05,;5.69,-5.62,;1.42,-3.96,)| Show InChI InChI=1S/C28H34FN5O3S/c29-23-2-1-19(13-24(23)36-16-28-5-3-21(37-28)4-6-28)22-15-34(27-25(22)26(30)31-17-32-27)20-11-18(12-20)14-33-7-9-38(35)10-8-33/h1-2,13,15,17-18,20-21H,3-12,14,16H2,(H2,30,31,32)/t18-,20+,21?,28? | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of IGF-1 receptor (unknown origin) in presence of [gamma33P]ATP |
Bioorg Med Chem Lett 26: 2057-64 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.075 BindingDB Entry DOI: 10.7270/Q29K4D4J |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50156375
(CHEMBL3785995)Show SMILES Nc1ncnc2n(cc(-c3ccc(F)c(OCC45CCC(CC4)O5)c3)c12)[C@@H]1C[C@H](CN2CC[S+]([O-])CC2)C1 |r,wD:26.30,28.33,(-1.03,2.79,;-1.03,1.55,;-2.38,.77,;-2.38,-.77,;-1.03,-1.55,;.3,-.77,;1.76,-1.24,;2.66,.02,;1.76,1.24,;2.23,2.7,;3.76,2.91,;4.33,4.34,;3.38,5.56,;3.84,6.7,;1.86,5.34,;.91,6.55,;-.62,6.33,;-1.57,7.54,;-2.89,6.94,;-3.98,7.99,;-3.62,9.48,;-2.14,9.89,;-1.05,8.84,;-2.2,8.68,;1.29,3.91,;.3,.77,;2.24,-2.7,;3.54,-3.45,;2.74,-4.76,;3.1,-6.25,;4.58,-6.69,;4.94,-8.18,;6.42,-8.61,;7.53,-7.55,;8.72,-7.9,;7.17,-6.05,;5.69,-5.62,;1.42,-3.96,)| Show InChI InChI=1S/C28H34FN5O3S/c29-23-2-1-19(13-24(23)36-16-28-5-3-21(37-28)4-6-28)22-15-34(27-25(22)26(30)31-17-32-27)20-11-18(12-20)14-33-7-9-38(35)10-8-33/h1-2,13,15,17-18,20-21H,3-12,14,16H2,(H2,30,31,32)/t18-,20+,21?,28? | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of full length IGF-1 receptor (unknown origin) autophosphorylation transfected in HEK293 cells pretreated for 60 mins followed by IGF-1 st... |
Bioorg Med Chem Lett 26: 2057-64 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.075 BindingDB Entry DOI: 10.7270/Q29K4D4J |
More data for this Ligand-Target Pair | |