Found 2 hits Enz. Inhib. hit(s) with Target = 'Insulin-like growth factor 1 receptor' and Ligand = 'BDBM50199686' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199686
(CHEMBL393314 | cis-1-(3-(benzyloxy)phenyl)-3-(3-(m...)Show SMILES Nc1nccn2c(nc(-c3cccc(OCc4ccccc4)c3)c12)[C@@H]1C[C@H](CN2CCOCC2)C1 |wU:24.27,26.30,(-9.93,2.7,;-9.92,1.16,;-11.25,.39,;-11.25,-1.15,;-9.92,-1.92,;-8.58,-1.15,;-7.1,-1.63,;-6.19,-.37,;-7.1,.88,;-6.63,2.35,;-7.66,3.48,;-7.19,4.94,;-5.68,5.27,;-4.65,4.12,;-3.14,4.44,;-2.11,3.3,;-.61,3.62,;.42,2.48,;1.92,2.79,;2.4,4.26,;1.36,5.41,;-.14,5.08,;-5.12,2.66,;-8.58,.4,;-6.63,-3.09,;-7.33,-4.46,;-5.95,-5.16,;-5.48,-6.62,;-3.97,-6.94,;-3.51,-8.41,;-2.01,-8.73,;-.97,-7.59,;-1.44,-6.12,;-2.95,-5.8,;-5.26,-3.79,)| Show InChI InChI=1S/C28H31N5O2/c29-27-26-25(22-7-4-8-24(17-22)35-19-20-5-2-1-3-6-20)31-28(33(26)10-9-30-27)23-15-21(16-23)18-32-11-13-34-14-12-32/h1-10,17,21,23H,11-16,18-19H2,(H2,29,30)/t21-,23+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 148 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human recombinant GST-IGF1R activity |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016 BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50199686
(CHEMBL393314 | cis-1-(3-(benzyloxy)phenyl)-3-(3-(m...)Show SMILES Nc1nccn2c(nc(-c3cccc(OCc4ccccc4)c3)c12)[C@@H]1C[C@H](CN2CCOCC2)C1 |wU:24.27,26.30,(-9.93,2.7,;-9.92,1.16,;-11.25,.39,;-11.25,-1.15,;-9.92,-1.92,;-8.58,-1.15,;-7.1,-1.63,;-6.19,-.37,;-7.1,.88,;-6.63,2.35,;-7.66,3.48,;-7.19,4.94,;-5.68,5.27,;-4.65,4.12,;-3.14,4.44,;-2.11,3.3,;-.61,3.62,;.42,2.48,;1.92,2.79,;2.4,4.26,;1.36,5.41,;-.14,5.08,;-5.12,2.66,;-8.58,.4,;-6.63,-3.09,;-7.33,-4.46,;-5.95,-5.16,;-5.48,-6.62,;-3.97,-6.94,;-3.51,-8.41,;-2.01,-8.73,;-.97,-7.59,;-1.44,-6.12,;-2.95,-5.8,;-5.26,-3.79,)| Show InChI InChI=1S/C28H31N5O2/c29-27-26-25(22-7-4-8-24(17-22)35-19-20-5-2-1-3-6-20)31-28(33(26)10-9-30-27)23-15-21(16-23)18-32-11-13-34-14-12-32/h1-10,17,21,23H,11-16,18-19H2,(H2,29,30)/t21-,23+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 658 | n/a | n/a | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of IGF1-stimulated phosphorylation of human recombinant IGF1R expressed in NIH3T3 cells |
Bioorg Med Chem Lett 17: 1091-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.016 BindingDB Entry DOI: 10.7270/Q2QZ29MB |
More data for this Ligand-Target Pair | |