Found 2 hits Enz. Inhib. hit(s) with Target = 'Insulin-like growth factor 1 receptor' and Ligand = 'BDBM50378023' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50378023
(CHEMBL1964271)Show SMILES COc1cc(ccc1Nc1nc(N2CCc3ccccc23)c2cc[nH]c2n1)N1CCN(CC1)C(C)C Show InChI InChI=1S/C28H33N7O/c1-19(2)33-14-16-34(17-15-33)21-8-9-23(25(18-21)36-3)30-28-31-26-22(10-12-29-26)27(32-28)35-13-11-20-6-4-5-7-24(20)35/h4-10,12,18-19H,11,13-17H2,1-3H3,(H2,29,30,31,32) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of IGF1R |
Bioorg Med Chem Lett 19: 373-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.065 BindingDB Entry DOI: 10.7270/Q2F190PC |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50378023
(CHEMBL1964271)Show SMILES COc1cc(ccc1Nc1nc(N2CCc3ccccc23)c2cc[nH]c2n1)N1CCN(CC1)C(C)C Show InChI InChI=1S/C28H33N7O/c1-19(2)33-14-16-34(17-15-33)21-8-9-23(25(18-21)36-3)30-28-31-26-22(10-12-29-26)27(32-28)35-13-11-20-6-4-5-7-24(20)35/h4-10,12,18-19H,11,13-17H2,1-3H3,(H2,29,30,31,32) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.77E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of IGF1R phosphorylation by cellular assay |
Bioorg Med Chem Lett 19: 373-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.065 BindingDB Entry DOI: 10.7270/Q2F190PC |
More data for this Ligand-Target Pair | |