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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Insulin-like growth factor 1 receptor' and Ligand = 'BDBM50437361'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50437361
PNG
(CHEMBL3037921)
Show SMILES CCOc1cc(nc2c(F)c(ccc12)-c1nc([C@@H]2C[C@@H](C2)N2CCN(C)CC2)n2ccnc(N)c12)-c1ccccc1 |r,wU:17.18,19.23,(16.88,-36.18,;15.55,-36.95,;15.55,-38.49,;16.88,-39.26,;18.21,-38.49,;19.55,-39.25,;19.56,-40.81,;18.22,-41.58,;18.22,-43.11,;19.56,-43.88,;16.9,-43.89,;15.55,-43.12,;15.55,-41.58,;16.88,-40.81,;16.91,-45.43,;18.16,-46.33,;17.69,-47.8,;18.6,-49.04,;18.37,-50.56,;19.88,-50.79,;20.12,-49.27,;20.79,-52.03,;20.17,-53.44,;21.08,-54.68,;22.61,-54.52,;23.52,-55.77,;23.23,-53.11,;22.33,-51.86,;16.15,-47.81,;15.13,-48.95,;13.62,-48.63,;13.15,-47.17,;14.18,-46.03,;13.7,-44.56,;15.67,-46.34,;20.88,-38.48,;22.21,-39.25,;23.55,-38.48,;23.54,-36.93,;22.19,-36.17,;20.87,-36.95,)|
Show InChI InChI=1S/C32H34FN7O/c1-3-41-26-19-25(20-7-5-4-6-8-20)36-28-23(26)9-10-24(27(28)33)29-30-31(34)35-11-12-40(30)32(37-29)21-17-22(18-21)39-15-13-38(2)14-16-39/h4-12,19,21-22H,3,13-18H2,1-2H3,(H2,34,35)/t21-,22+
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n/an/a 9n/an/an/an/an/an/a



OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of full length human IGF-1R overexpressed in mouse NIH 3T3 cells assessed as IGF1-induced protein phosphorylation incubated for 2 hrs prio...

ACS Med Chem Lett 4: 627-31 (2013)


Article DOI: 10.1021/ml400160a
BindingDB Entry DOI: 10.7270/Q2S75HR4
More data for this
Ligand-Target Pair