Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Interferon-induced, double-stranded RNA-activated protein kinase' and Ligand = 'BDBM365352'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Interferon-induced, double-stranded RNA-activated protein kinase (Homo sapiens (Human))	BDBM365352 (N-[dimethyl(oxido)-lambda4- sulfanylidene]-5-{5-[(...) Show SMILES CS(C)(=O)=NC(=O)c1cncc(c1)-c1cc2cc(NC(=O)Nc3cc(ccc3F)C(F)(F)F)ccc2s1 Show InChI InChI=1S/C24H18F4N4O3S2/c1-37(2,35)32-22(33)15-7-14(11-29-12-15)21-9-13-8-17(4-6-20(13)36-21)30-23(34)31-19-10-16(24(26,27)28)3-5-18(19)25/h3-12H,1-2H3,(H2,30,31,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	551	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2...				J Med Chem 50: 3515-27 (2007) BindingDB Entry DOI: 10.7270/Q2DB8465
					More data for this Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase (Homo sapiens (Human))	BDBM365352 (N-[dimethyl(oxido)-lambda4- sulfanylidene]-5-{5-[(...) Show SMILES CS(C)(=O)=NC(=O)c1cncc(c1)-c1cc2cc(NC(=O)Nc3cc(ccc3F)C(F)(F)F)ccc2s1 Show InChI InChI=1S/C24H18F4N4O3S2/c1-37(2,35)32-22(33)15-7-14(11-29-12-15)21-9-13-8-17(4-6-20(13)36-21)30-23(34)31-19-10-16(24(26,27)28)3-5-18(19)25/h3-12H,1-2H3,(H2,30,31,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	551	n/a	n/a	n/a	n/a	n/a	n/a
ALLERGAN, INC. US Patent					Assay Description Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2...				US Patent US10669265 (2020) BindingDB Entry DOI: 10.7270/Q20R9SFZ
					More data for this Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase (Homo sapiens (Human))	BDBM365352 (N-[dimethyl(oxido)-lambda4- sulfanylidene]-5-{5-[(...) Show SMILES CS(C)(=O)=NC(=O)c1cncc(c1)-c1cc2cc(NC(=O)Nc3cc(ccc3F)C(F)(F)F)ccc2s1 Show InChI InChI=1S/C24H18F4N4O3S2/c1-37(2,35)32-22(33)15-7-14(11-29-12-15)21-9-13-8-17(4-6-20(13)36-21)30-23(34)31-19-10-16(24(26,27)28)3-5-18(19)25/h3-12H,1-2H3,(H2,30,31,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	551	n/a	n/a	n/a	n/a	n/a	n/a
Allergan, Inc. US Patent					Assay Description PKR: Commercially available recombinant human GST-PKR (1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2, 10 mM KCl, 10...				US Patent US10633373 (2020) BindingDB Entry DOI: 10.7270/Q2Z60S37
					More data for this Ligand-Target Pair