Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Interleukin-1 receptor-associated kinase 4' and Ligand = 'BDBM278832'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human))	BDBM278832 (2-(2,5- diazabicyclo[2.2.2] oct-2-yl)-N-[3- (diflu...) Show SMILES Cn1cc(NC(=O)c2csc3ncc(nc23)N2CC3CCC2CN3)c(n1)C(F)F Show InChI InChI=1S/C18H19F2N7OS/c1-26-7-12(15(25-26)16(19)20)23-17(28)11-8-29-18-14(11)24-13(5-22-18)27-6-9-2-3-10(27)4-21-9/h5,7-10,16,21H,2-4,6H2,1H3,(H,23,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	7.2	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...				US Patent US10040802 (2018) BindingDB Entry DOI: 10.7270/Q298891C
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