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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Interleukin-6' and Ligand = 'BDBM50252381'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Interleukin-6


(Homo sapiens (Human))		BDBM50252381
PNG
(CHEMBL4080826)
Show SMILES CCc1ccc(Nc2nc3cc(NC(=O)c4ccccc4)ccc3o2)cc1
Show InChI InChI=1S/C22H19N3O2/c1-2-15-8-10-17(11-9-15)24-22-25-19-14-18(12-13-20(19)27-22)23-21(26)16-6-4-3-5-7-16/h3-14H,2H2,1H3,(H,23,26)(H,24,25)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
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PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 5.80E+3n/an/an/an/an/an/a



College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Republic of Korea.

Curated by ChEMBL


Assay Description
Inhibition of IL-6 signaling pathway in human HepG2 cells transfected with p-STAT3-Luc assessed as reduction in IL-6 induced STAT3 phosphorylation pr...

Bioorg Med Chem 25: 3127-3134 (2017)


Article DOI: 10.1016/j.bmc.2017.03.072
BindingDB Entry DOI: 10.7270/Q2KW5JF6
More data for this
Ligand-Target Pair