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Found 1 hit Enz. Inhib. hit(s) with Target = 'Isocitrate dehydrogenase [NADP], mitochondrial' and Ligand = 'BDBM310935'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Isocitrate dehydrogenase [NADP], mitochondrial


(Homo sapiens (Human))		BDBM310935
PNG
(US10155722, Example 5)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cc(ccc2-c2ccsc2)C(F)(F)C(=O)NC2COC2)c1
Show InChI InChI=1S/C23H18F5N3O3S/c24-22(25,20(32)29-17-10-34-11-17)14-4-5-18(13-6-7-35-12-13)19(9-14)31-21(33)30-16-3-1-2-15(8-16)23(26,27)28/h1-9,12,17H,10-11H2,(H,29,32)(H2,30,31,33)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 29.5n/an/an/an/an/an/a



Chia Tai Tianqing Pharmaceutical Group Co., Ltd.; Lianyungang Runzhong Pharmaceutical Co., Ltd.; Centaurus Biopharma Co., Ltd.

US Patent


Assay Description
The inhibitory activity of a compound against IDH2 (R172K, 40-end) was determined by the decrease of a helper factor NADPH. The test compound was pre...

US Patent US10155722 (2018)


BindingDB Entry DOI: 10.7270/Q2G162W2
More data for this
Ligand-Target Pair