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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]' and Ligand = 'BDBM420264'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))		BDBM420264
PNG
(US10487092, Example 112 | [(2R,6S)-2,6-Dimethylmor...)
Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1C[C@H](C)O[C@H](C)C1 |r|
Show InChI InChI=1S/C25H28N6O3S/c1-14-10-30(11-15(2)34-14)25(32)16-4-5-18-21(8-16)35-24-22(18)23(26-13-27-24)29-19-9-17-6-7-28-31(17)12-20(19)33-3/h6-7,9,12-16H,4-5,8,10-11H2,1-3H3,(H,26,27,29)/t14-,15+,16-/m0/s1
PDB

UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...

US Patent US10487092 (2019)


BindingDB Entry DOI: 10.7270/Q28W3GPZ
More data for this
Ligand-Target Pair