Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Isoform 7 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (PDE4A8)' and Ligand = 'BDBM399937'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Isoform 7 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (PDE4A8) (Homo sapiens (Human))	BDBM399937 (US10323042, Example 17 | US10738063, Example 17) Show SMILES Cc1cc(Cl)c(F)cc1-c1c2OCCCn2nc1C(=O)NC1CC1 |(-3.16,.88,;-1.67,1.28,;-1.27,2.76,;.22,3.16,;.62,4.65,;1.31,2.07,;2.79,2.47,;.91,.59,;-.58,.19,;-.98,-1.3,;-2.44,-1.78,;-3.78,-1.01,;-5.11,-1.78,;-5.11,-3.32,;-3.78,-4.09,;-2.44,-3.32,;-.98,-3.79,;-.07,-2.55,;1.47,-2.55,;2.24,-1.21,;2.24,-3.88,;3.78,-3.88,;5.11,-4.65,;5.11,-3.11,)| Show InChI InChI=1S/C17H17ClFN3O2/c1-9-7-12(18)13(19)8-11(9)14-15(16(23)20-10-3-4-10)21-22-5-2-6-24-17(14)22/h7-8,10H,2-6H2,1H3,(H,20,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
CNR					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				J Med Chem 52: 5990-8 (2009) BindingDB Entry DOI: 10.7270/Q2NP26RH
					More data for this Ligand-Target Pair