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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Isoform APP695 of Amyloid-beta precursor protein [K595N,M596L]' and Ligand = 'BDBM476541'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Isoform APP695 of Amyloid-beta precursor protein [K595N,M596L]


(Homo sapiens (Human))		BDBM476541
PNG
(US10875854, Example 14)
Show SMILES COc1cc(ccn1)N1C[C@@H]2CC[C@H](C1)[C@H]2Nc1nc2c(ccc(OCC(F)(F)F)n2n1)C(C)C |r,TLB:4:8:15:11.12,16:15:8.9.14:11.12|
Show InChI InChI=1S/C24H29F3N6O2/c1-14(2)18-6-7-20(35-13-24(25,26)27)33-22(18)30-23(31-33)29-21-15-4-5-16(21)12-32(11-15)17-8-9-28-19(10-17)34-3/h6-10,14-16,21H,4-5,11-13H2,1-3H3,(H,29,31)/t15-,16+,21-
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 25.4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...

US Patent US10875854 (2020)


BindingDB Entry DOI: 10.7270/Q28W3HCB
More data for this
Ligand-Target Pair