Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Isoform D of Beta-secretase 1 (BACE-I-432)' and Ligand = 'BDBM207625'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Isoform D of Beta-secretase 1 (BACE-I-432) (Homo sapiens (Human))	BDBM207625 (US9260455, 1) Show SMILES C[C@H]1SC(N)=N[C@]2(CO[C@@H](CF)C[C@@H]12)c1ccc(F)cc1F |c:4| Show InChI InChI=1S/C15H17F3N2OS/c1-8-12-5-10(6-16)21-7-15(12,20-14(19)22-8)11-3-2-9(17)4-13(11)18/h2-4,8,10,12H,5-7H2,1H3,(H2,19,20)/t8-,10-,12+,15-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	805	n/a	n/a	n/a	n/a	4.5	37
Pfizer Inc. US Patent					Assay Description A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...				US Patent US9260455 (2016) BindingDB Entry DOI: 10.7270/Q2GB22WN
					More data for this Ligand-Target Pair