Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2)' and Ligand = 'BDBM234756'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM234756 (US9353104, 50) Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1cc(NCc2ccc(C)nc2C)c(=O)n(C)n1 |r| Show InChI InChI=1S/C23H27N5O3/c1-14-5-6-16(15(2)26-14)11-24-21-10-22(27-28(3)23(21)29)31-13-17-9-19(17)20-8-7-18(30-4)12-25-20/h5-8,10,12,17,19,24H,9,11,13H2,1-4H3/t17-,19+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.00300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...				US Patent US9353104 (2016) BindingDB Entry DOI: 10.7270/Q2ZP4517
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