Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2)' and Ligand = 'BDBM234835'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM234835 (US9353104, 140) Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1nn(C)c(=O)c(NCc2nnc(C)s2)c1Br |r| Show InChI InChI=1S/C19H21BrN6O3S/c1-10-23-24-15(30-10)8-22-17-16(20)18(25-26(2)19(17)27)29-9-11-6-13(11)14-5-4-12(28-3)7-21-14/h4-5,7,11,13,22H,6,8-9H2,1-3H3/t11-,13+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.00400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...				US Patent US9353104 (2016) BindingDB Entry DOI: 10.7270/Q2ZP4517
					More data for this Ligand-Target Pair