BindingDB PrimarySearch

Found 19 hits Enz. Inhib. hit(s) with Target = 'Kappa-type opioid receptor' and Ligand = 'BDBM224024'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM224024 (BDBM50241435 \| Dynorphin A (1-13) \| YGGFLRRXRPKLK) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	PubMed	0.000800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Binding affinity towards Wild-type kappa opioid receptor expressed in HEK cells				J Med Chem 43: 1251-2 (2001) BindingDB Entry DOI: 10.7270/Q270824F
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Cavia porcellus (domestic guinea pig))	BDBM224024 (BDBM50241435 \| Dynorphin A (1-13) \| YGGFLRRXRPKLK) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	0.310	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Oregon State University Curated by ChEMBL					Assay Description Binding affinity to Opioid receptor kappa 1 by competitive inhibition of radioligand [3H]-diprenorphine using cloned receptors transiently expressed ...				J Med Chem 40: 1211-8 (1997) Article DOI: 10.1021/jm960753p BindingDB Entry DOI: 10.7270/Q2BG2N3H
Oregon State University Curated by ChEMBL					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Cavia porcellus (domestic guinea pig))	BDBM224024 (BDBM50241435 \| Dynorphin A (1-13) \| YGGFLRRXRPKLK) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	PubMed	0.400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
SRI International Curated by PDSP K_i Database									NIDA Res Monogr 178: 440-66 (1998) BindingDB Entry DOI: 10.7270/Q23J3BH2
SRI International Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM224024 (BDBM50241435 \| Dynorphin A (1-13) \| YGGFLRRXRPKLK) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	PubMed	0.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
SRI International Curated by PDSP K_i Database									NIDA Res Monogr 178: 440-66 (1998) BindingDB Entry DOI: 10.7270/Q23J3BH2
SRI International Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Rattus norvegicus (rat))	BDBM224024 (BDBM50241435 \| Dynorphin A (1-13) \| YGGFLRRXRPKLK) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	PubMed	0.600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Binding constant against E203Q,D204N,D206N EL-2 Opioid receptor kappa 1 using [3H]diprenorphine as radioligand expressed in HEK cells				J Med Chem 43: 1251-2 (2001) BindingDB Entry DOI: 10.7270/Q270824F
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Rattus norvegicus (rat))	BDBM224024 (BDBM50241435 \| Dynorphin A (1-13) \| YGGFLRRXRPKLK) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	PubMed	0.800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Binding constant against wild type EL-2 Opioid receptor kappa 1 using [3H]diprenorphine as radioligand expressed in HEK cells				J Med Chem 43: 1251-2 (2001) BindingDB Entry DOI: 10.7270/Q270824F
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Rattus norvegicus (rat))	BDBM224024 (BDBM50241435 \| Dynorphin A (1-13) \| YGGFLRRXRPKLK) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	PubMed	1.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Binding constant against E203Q,D204N,D206N,E209Q EL-2 Opioid receptor kappa 1 using [3H]diprenorphine as radioligand expressed in HEK cells				J Med Chem 43: 1251-2 (2001) BindingDB Entry DOI: 10.7270/Q270824F
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Rattus norvegicus (rat))	BDBM224024 (BDBM50241435 \| Dynorphin A (1-13) \| YGGFLRRXRPKLK) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	PubMed	3.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Binding constant against D216N,D217N,E218Q EL-2 Opioid receptor kappa 1 using [3H]diprenorphine as radioligand expressed in HEK cells				J Med Chem 43: 1251-2 (2001) BindingDB Entry DOI: 10.7270/Q270824F
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Cavia porcellus (domestic guinea pig))	BDBM224024 (BDBM50241435 \| Dynorphin A (1-13) \| YGGFLRRXRPKLK) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	PubMed	3.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by ChEMBL					Assay Description The compound was tested for binding activity towards opioid receptor kappa in guinea pig brain membranes.				J Med Chem 34: 2816-21 (1991) BindingDB Entry DOI: 10.7270/Q2J965CZ
Case Western Reserve University Curated by ChEMBL					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Rattus norvegicus (rat))	BDBM224024 (BDBM50241435 \| Dynorphin A (1-13) \| YGGFLRRXRPKLK) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	57	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Biological Research Center of Hungarian Academy of Sciences Curated by PDSP K_i Database									Neurochem Res 15: 899-904 (1990) Article DOI: 10.1007/bf00965909 BindingDB Entry DOI: 10.7270/Q25M6460
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM224024 (BDBM50241435 \| Dynorphin A (1-13) \| YGGFLRRXRPKLK) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	343	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by PDSP K_i Database									Biochemistry 44: 8643-51 (2005) Article DOI: 10.1021/bi050490d BindingDB Entry DOI: 10.7270/Q2QN65BH
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Cavia porcellus (domestic guinea pig))	BDBM224024 (BDBM50241435 \| Dynorphin A (1-13) \| YGGFLRRXRPKLK) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	PubMed	n/a	n/a	0.114	n/a	n/a	n/a	n/a	n/a	n/a
University of Arizona Curated by ChEMBL					Assay Description Inhibition of [3H]-U-69,593 binding to kappa opoid receptor of guinea pig brain homogenate				J Med Chem 36: 750-7 (1993) BindingDB Entry DOI: 10.7270/Q2K936K7
University of Arizona Curated by ChEMBL					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Rattus norvegicus (rat))	BDBM224024 (BDBM50241435 \| Dynorphin A (1-13) \| YGGFLRRXRPKLK) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	PubMed	n/a	n/a	n/a	n/a	18	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Effective concentration to inhibit wild type KL-2 Opioid receptor kappa 1 binding to [35S]GTP-gamma-S, expressed in COS cells				J Med Chem 43: 1251-2 (2001) BindingDB Entry DOI: 10.7270/Q270824F
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Rattus norvegicus (rat))	BDBM224024 (BDBM50241435 \| Dynorphin A (1-13) \| YGGFLRRXRPKLK) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	PubMed	n/a	n/a	n/a	n/a	6	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Effective concentration to inhibit E203Q,D204N,D206N KL-2 Opioid receptor kappa 1 binding to [35S]GTP-gamma-S, expressed in COS cells				J Med Chem 43: 1251-2 (2001) BindingDB Entry DOI: 10.7270/Q270824F
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Rattus norvegicus (rat))	BDBM224024 (BDBM50241435 \| Dynorphin A (1-13) \| YGGFLRRXRPKLK) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	PubMed	n/a	n/a	n/a	n/a	8	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Effective concentration to inhibit D216,ND217N,E218Q KL-2 Opioid receptor kappa 1 binding to [35S]GTP-gamma-S, expressed in COS cells				J Med Chem 43: 1251-2 (2001) BindingDB Entry DOI: 10.7270/Q270824F
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Cavia porcellus (domestic guinea pig))	BDBM224024 (BDBM50241435 \| Dynorphin A (1-13) \| YGGFLRRXRPKLK) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	PubMed	n/a	n/a	n/a	n/a	18	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Binding affinity towards k-opioid receptor k-EL-2 mutant (wild-type) expressed in HEK cells				J Med Chem 43: 1251-2 (2001) BindingDB Entry DOI: 10.7270/Q270824F
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM224024 (BDBM50241435 \| Dynorphin A (1-13) \| YGGFLRRXRPKLK) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	4.5	n/a	n/a	n/a	n/a
Medical University of Lodz Curated by ChEMBL					Assay Description Agonist activity at human recombinant KOR expressed in CHO cells assessed as calcium mobilization by Fluo-4 AM based fluorescence analysis				Eur J Med Chem 109: 276-86 (2016) Article DOI: 10.1016/j.ejmech.2015.12.012 BindingDB Entry DOI: 10.7270/Q22809FJ
Medical University of Lodz Curated by ChEMBL					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM224024 (BDBM50241435 \| Dynorphin A (1-13) \| YGGFLRRXRPKLK) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	40	n/a	n/a	n/a	n/a
The University of Kansas Curated by ChEMBL					Assay Description Agonist activity at kappa-opioid receptor (unknown origin) after 90 mins by [35S]GTPgammaS binding assay				J Med Chem 58: 8783-95 (2015) Article DOI: 10.1021/jm501827k BindingDB Entry DOI: 10.7270/Q2348N7Z
The University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM224024 (BDBM50241435 \| Dynorphin A (1-13) \| YGGFLRRXRPKLK) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.5	n/a	n/a	n/a	n/a
Medical University of Lodz Curated by ChEMBL					Assay Description Agonist activity at human recombinant KOR expressed in CHO cells by calcium mobilization assay				Bioorg Med Chem 24: 1582-8 (2016) Article DOI: 10.1016/j.bmc.2016.02.034 BindingDB Entry DOI: 10.7270/Q2Z321H7
Medical University of Lodz Curated by ChEMBL					More data for this Ligand-Target Pair