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Found 1 hit Enz. Inhib. hit(s) with Target = 'Kappa-type opioid receptor' and Ligand = 'BDBM50422810'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50422810
PNG
(CHEMBL381534)
Show SMILES COc1cccc(c1)[C@H](N1C[C@@H](C)N(Cc2ccccc2)C[C@@H]1C)c1ccc2CN(Cc2c1)C(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C37H39N3O4/c1-25-21-40(26(2)20-38(25)22-27-8-5-4-6-9-27)35(30-10-7-11-34(19-30)44-3)31-16-17-32-23-39(24-33(32)18-31)36(41)28-12-14-29(15-13-28)37(42)43/h4-19,25-26,35H,20-24H2,1-3H3,(H,42,43)/t25-,26+,35+/m1/s1
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PubMed
n/an/a 398n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at kappa opioid receptor in myentric plexus muscle from guinea pig

Bioorg Med Chem Lett 16: 905-10 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.102
BindingDB Entry DOI: 10.7270/Q2930VG2
More data for this
Ligand-Target Pair