Found 3 hits Enz. Inhib. hit(s) with Target = 'KiSS-1 receptor' and Ligand = 'BDBM50392403' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
KiSS-1 receptor
(Homo sapiens (Human)) | BDBM50392403
(CHEMBL2151644)Show SMILES CNC(N)=NCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r,w:4.4| Show InChI InChI=1S/C64H87N17O13/c1-36(2)25-48(59(90)76-46(19-12-24-72-64(69)70-3)58(89)77-47(56(68)87)28-38-15-8-5-9-16-38)75-55(86)34-71-33-41(26-37-13-6-4-7-14-37)74-63(94)52(35-82)81-62(93)51(31-54(67)85)80-60(91)49(29-40-32-73-45-18-11-10-17-43(40)45)79-61(92)50(30-53(66)84)78-57(88)44(65)27-39-20-22-42(83)23-21-39/h4-11,13-18,20-23,32,36,41,44,46-52,71,73,82-83H,12,19,24-31,33-35,65H2,1-3H3,(H2,66,84)(H2,67,85)(H2,68,87)(H,74,94)(H,75,86)(H,76,90)(H,77,89)(H,78,88)(H,79,92)(H,80,91)(H,81,93)(H3,69,70,72)/t41-,44+,46-,47-,48-,49-,50-,51-,52-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.610 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Ltd
Curated by ChEMBL
| Assay Description Binding affinity to human KISS1R |
Bioorg Med Chem Lett 22: 6391-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.08.069 BindingDB Entry DOI: 10.7270/Q2ZP477R |
More data for this Ligand-Target Pair | |
KiSS-1 receptor
(Rattus norvegicus) | BDBM50392403
(CHEMBL2151644)Show SMILES CNC(N)=NCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r,w:4.4| Show InChI InChI=1S/C64H87N17O13/c1-36(2)25-48(59(90)76-46(19-12-24-72-64(69)70-3)58(89)77-47(56(68)87)28-38-15-8-5-9-16-38)75-55(86)34-71-33-41(26-37-13-6-4-7-14-37)74-63(94)52(35-82)81-62(93)51(31-54(67)85)80-60(91)49(29-40-32-73-45-18-11-10-17-43(40)45)79-61(92)50(30-53(66)84)78-57(88)44(65)27-39-20-22-42(83)23-21-39/h4-11,13-18,20-23,32,36,41,44,46-52,71,73,82-83H,12,19,24-31,33-35,65H2,1-3H3,(H2,66,84)(H2,67,85)(H2,68,87)(H,74,94)(H,75,86)(H,76,90)(H,77,89)(H,78,88)(H,79,92)(H,80,91)(H,81,93)(H3,69,70,72)/t41-,44+,46-,47-,48-,49-,50-,51-,52-/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Ltd
Curated by ChEMBL
| Assay Description Binding affinity to rat KISS1R |
Bioorg Med Chem Lett 22: 6391-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.08.069 BindingDB Entry DOI: 10.7270/Q2ZP477R |
More data for this Ligand-Target Pair | |
KiSS-1 receptor
(Homo sapiens (Human)) | BDBM50392403
(CHEMBL2151644)Show SMILES CNC(N)=NCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r,w:4.4| Show InChI InChI=1S/C64H87N17O13/c1-36(2)25-48(59(90)76-46(19-12-24-72-64(69)70-3)58(89)77-47(56(68)87)28-38-15-8-5-9-16-38)75-55(86)34-71-33-41(26-37-13-6-4-7-14-37)74-63(94)52(35-82)81-62(93)51(31-54(67)85)80-60(91)49(29-40-32-73-45-18-11-10-17-43(40)45)79-61(92)50(30-53(66)84)78-57(88)44(65)27-39-20-22-42(83)23-21-39/h4-11,13-18,20-23,32,36,41,44,46-52,71,73,82-83H,12,19,24-31,33-35,65H2,1-3H3,(H2,66,84)(H2,67,85)(H2,68,87)(H,74,94)(H,75,86)(H,76,90)(H,77,89)(H,78,88)(H,79,92)(H,80,91)(H,81,93)(H3,69,70,72)/t41-,44+,46-,47-,48-,49-,50-,51-,52-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 0.620 | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Ltd
Curated by ChEMBL
| Assay Description Agonist activity at human KISS1R assessed as induction of intracellular calcium mobilization by fluorometric analysis |
Bioorg Med Chem Lett 22: 6391-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.08.069 BindingDB Entry DOI: 10.7270/Q2ZP477R |
More data for this Ligand-Target Pair | |