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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Large T antigen' and Ligand = 'BDBM50533455'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Large T antigen


(JC polyomavirus)		BDBM50533455
PNG
(CHEMBL4562725)
Show SMILES O(c1ccccc1)c1ncccc1-c1nn2cnnc2s1
Show InChI InChI=1S/C14H9N5OS/c1-2-5-10(6-3-1)20-12-11(7-4-8-15-12)13-18-19-9-16-17-14(19)21-13/h1-9H
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UniProtKB/SwissProt

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 8.80E+3n/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc

Curated by ChEMBL


Assay Description
Inhibition of helicase activity of JC polyomavirus LTAg (E264 to D628 residues) expressed in Escherichia coli using Cy5/BHQ3 dsDNA pre-incubated for ...

J Med Chem 59: 7138-51 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00486
BindingDB Entry DOI: 10.7270/Q22Z1900
More data for this
Ligand-Target Pair