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Found 1 hit Enz. Inhib. hit(s) with Target = 'Legumain' and Ligand = 'BDBM50499747'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Legumain


(Homo sapiens (Human))		BDBM50499747
PNG
(CHEMBL3739710)
Show SMILES NC(=O)C[C@H](NC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(cc1)C(F)(F)F)C#N |r|
Show InChI InChI=1S/C16H17F3N4O4S/c17-16(18,19)10-3-5-12(6-4-10)28(26,27)23-7-1-2-13(23)15(25)22-11(9-20)8-14(21)24/h3-6,11,13H,1-2,7-8H2,(H2,21,24)(H,22,25)/t11-,13-/m0/s1
PDB
MMDB

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 332n/an/an/an/an/an/a



Queen's University Belfast

Curated by ChEMBL


Assay Description
Inhibition of recombinant human legumain using Z-Ala-Ala-Asn-MCA substrate measured every 2 mins for 60 mins by microplate reader analysis

Bioorg Med Chem Lett 25: 5642-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.001
BindingDB Entry DOI: 10.7270/Q2280BM6
More data for this
Ligand-Target Pair