Found 5 hits Enz. Inhib. hit(s) with Target = 'Leukotriene A-4 hydrolase' and Ligand = 'BDBM50105264' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Leukotriene A-4 hydrolase
(Homo sapiens (Human)) | BDBM50105264
(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)Show SMILES C[C@H](NC(=O)[C@@H](CC(=O)NO)Cc1ccccc1)C([O-])=O Show InChI InChI=1S/C14H18N2O5/c1-9(14(19)20)15-13(18)11(8-12(17)16-21)7-10-5-3-2-4-6-10/h2-6,9,11,21H,7-8H2,1H3,(H,15,18)(H,16,17)(H,19,20)/p-1/t9-,11+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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MCE PC cid PC sid PDB UniChem
Similars
| PDB Article
| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory activity against LTA 4 hydrolase in aminopeptidase assay |
Bioorg Med Chem Lett 5: 2517-2522 (1995)
Article DOI: 10.1016/0960-894X(95)00441-U BindingDB Entry DOI: 10.7270/Q2959J1M |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Leukotriene A-4 hydrolase
(Homo sapiens (Human)) | BDBM50105264
(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)Show SMILES C[C@H](NC(=O)[C@@H](CC(=O)NO)Cc1ccccc1)C([O-])=O Show InChI InChI=1S/C14H18N2O5/c1-9(14(19)20)15-13(18)11(8-12(17)16-21)7-10-5-3-2-4-6-10/h2-6,9,11,21H,7-8H2,1H3,(H,15,18)(H,16,17)(H,19,20)/p-1/t9-,11+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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MCE PC cid PC sid PDB UniChem
Similars
| PDB Article
| 18 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory activity against LTA 4 hydrolase in epoxide hydrolase assay |
Bioorg Med Chem Lett 5: 2517-2522 (1995)
Article DOI: 10.1016/0960-894X(95)00441-U BindingDB Entry DOI: 10.7270/Q2959J1M |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Leukotriene A-4 hydrolase
(Homo sapiens (Human)) | BDBM50105264
(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)Show SMILES C[C@H](NC(=O)[C@@H](CC(=O)NO)Cc1ccccc1)C([O-])=O Show InChI InChI=1S/C14H18N2O5/c1-9(14(19)20)15-13(18)11(8-12(17)16-21)7-10-5-3-2-4-6-10/h2-6,9,11,21H,7-8H2,1H3,(H,15,18)(H,16,17)(H,19,20)/p-1/t9-,11+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid PDB UniChem
Similars
| PDB Article
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory activity against recombinant human Leukotriene A4 hydrolase |
Bioorg Med Chem Lett 5: 2517-2522 (1995)
Article DOI: 10.1016/0960-894X(95)00441-U BindingDB Entry DOI: 10.7270/Q2959J1M |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Leukotriene A-4 hydrolase
(Homo sapiens (Human)) | BDBM50105264
(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)Show SMILES C[C@H](NC(=O)[C@@H](CC(=O)NO)Cc1ccccc1)C([O-])=O Show InChI InChI=1S/C14H18N2O5/c1-9(14(19)20)15-13(18)11(8-12(17)16-21)7-10-5-3-2-4-6-10/h2-6,9,11,21H,7-8H2,1H3,(H,15,18)(H,16,17)(H,19,20)/p-1/t9-,11+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid PDB UniChem
Similars
| PDB PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Searle Research and Development
Curated by ChEMBL
| Assay Description Inhibitory activity was determined against Leukotriene A4 hydrolase |
J Med Chem 43: 721-35 (2000)
BindingDB Entry DOI: 10.7270/Q2CN74MZ |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Leukotriene A-4 hydrolase
(Homo sapiens (Human)) | BDBM50105264
(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)Show SMILES C[C@H](NC(=O)[C@@H](CC(=O)NO)Cc1ccccc1)C([O-])=O Show InChI InChI=1S/C14H18N2O5/c1-9(14(19)20)15-13(18)11(8-12(17)16-21)7-10-5-3-2-4-6-10/h2-6,9,11,21H,7-8H2,1H3,(H,15,18)(H,16,17)(H,19,20)/p-1/t9-,11+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid PDB UniChem
Similars
| PDB PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Searle Research and Development
Curated by ChEMBL
| Assay Description Inhibitory activity was determined for LTB4 production in human whole blood. |
J Med Chem 43: 721-35 (2000)
BindingDB Entry DOI: 10.7270/Q2CN74MZ |
More data for this Ligand-Target Pair | 3D Structure (crystal) |