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Found 1 hit Enz. Inhib. hit(s) with Target = 'Lysine-specific histone demethylase 1A' and Ligand = 'BDBM301086'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))		BDBM301086
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-[1- (difluoromethyl...)
Show SMILES NC1CCN(CC1)c1ncc(-c2ccc3n(cnc3c2)C(F)F)c(n1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C24H21F2N7/c25-23(26)33-14-30-20-11-17(5-6-21(20)33)19-13-29-24(32-9-7-18(28)8-10-32)31-22(19)16-3-1-15(12-27)2-4-16/h1-6,11,13-14,18,23H,7-10,28H2
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MMDB

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US Patent
n/an/a<10n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...

US Patent US10131664 (2018)


BindingDB Entry DOI: 10.7270/Q2JD4ZV1
More data for this
Ligand-Target Pair