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Found 2 hits Enz. Inhib. hit(s) with Target = 'Lysine-specific histone demethylase 1A' and Ligand = 'BDBM456470'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM456470
PNG
(US10723742, Example 196 | US11510915, Example 196)
Show SMILES CC(C)(O)Cn1ccc2cc(c(F)c(F)c12)-c1ccc(cc1-c1ccc(C#N)c(F)c1)C(=O)N1[C@@H]2CC[C@H]1[C@@H](N)C2 |TLB:39:38:36.35:33|
Show InChI InChI=1S/C32H29F3N4O2/c1-32(2,41)16-38-10-9-18-11-24(28(34)29(35)30(18)38)22-7-5-19(31(40)39-21-6-8-27(39)26(37)14-21)12-23(22)17-3-4-20(15-36)25(33)13-17/h3-5,7,9-13,21,26-27,41H,6,8,14,16,37H2,1-2H3/t21-,26+,27+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.140n/an/an/an/an/an/a


TBA

Assay Description
The conditions for measuring inhibitory activity of compounds against LSD1 activity were determined with reference to a document available from the w...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2NC6513
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM456470
PNG
(US10723742, Example 196 | US11510915, Example 196)
Show SMILES CC(C)(O)Cn1ccc2cc(c(F)c(F)c12)-c1ccc(cc1-c1ccc(C#N)c(F)c1)C(=O)N1[C@@H]2CC[C@H]1[C@@H](N)C2 |TLB:39:38:36.35:33|
Show InChI InChI=1S/C32H29F3N4O2/c1-32(2,41)16-38-10-9-18-11-24(28(34)29(35)30(18)38)22-7-5-19(31(40)39-21-6-8-27(39)26(37)14-21)12-23(22)17-3-4-20(15-36)25(33)13-17/h3-5,7,9-13,21,26-27,41H,6,8,14,16,37H2,1-2H3/t21-,26+,27+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.140n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
The conditions for measuring inhibitory activity of compounds against LSD1 activity were determined with reference to a document available from the w...


US Patent US10723742 (2020)


BindingDB Entry DOI: 10.7270/Q2TF01DB
More data for this
Ligand-Target Pair