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Found 2 hits Enz. Inhib. hit(s) with Target = 'Lysine-specific histone demethylase 1A' and Ligand = 'BDBM456471'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM456471
PNG
(US10723742, Example 197 | US11510915, Example 197)
Show SMILES CC(C)(O)Cn1ncc2cc(c(F)c(F)c12)-c1ccc(cc1-c1ccc(C#N)c(F)c1)C(=O)N1CC[C@](C)(N)C1
Show InChI InChI=1S/C30H28F3N5O2/c1-29(2,40)15-38-27-20(14-36-38)11-23(25(32)26(27)33)21-7-6-18(28(39)37-9-8-30(3,35)16-37)10-22(21)17-4-5-19(13-34)24(31)12-17/h4-7,10-12,14,40H,8-9,15-16,35H2,1-3H3/t30-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.110n/an/an/an/an/an/a


TBA

Assay Description
The conditions for measuring inhibitory activity of compounds against LSD1 activity were determined with reference to a document available from the w...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2NC6513
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM456471
PNG
(US10723742, Example 197 | US11510915, Example 197)
Show SMILES CC(C)(O)Cn1ncc2cc(c(F)c(F)c12)-c1ccc(cc1-c1ccc(C#N)c(F)c1)C(=O)N1CC[C@](C)(N)C1
Show InChI InChI=1S/C30H28F3N5O2/c1-29(2,40)15-38-27-20(14-36-38)11-23(25(32)26(27)33)21-7-6-18(28(39)37-9-8-30(3,35)16-37)10-22(21)17-4-5-19(13-34)24(31)12-17/h4-7,10-12,14,40H,8-9,15-16,35H2,1-3H3/t30-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.110n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
The conditions for measuring inhibitory activity of compounds against LSD1 activity were determined with reference to a document available from the w...


US Patent US10723742 (2020)


BindingDB Entry DOI: 10.7270/Q2TF01DB
More data for this
Ligand-Target Pair