Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'MAP kinase-activated protein kinase 2' and Ligand = 'BDBM30313'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM30313 (Pyrrolo-pyrimidone, 6) Show SMILES O=c1[nH]cnc2[nH]c(cc12)-c1ccnc(c1)-c1ccc(CN2CCOCC2)cc1 Show InChI InChI=1S/C22H21N5O2/c28-22-18-12-20(26-21(18)24-14-25-22)17-5-6-23-19(11-17)16-3-1-15(2-4-16)13-27-7-9-29-10-8-27/h1-6,11-12,14H,7-10,13H2,(H2,24,25,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.45E+3	n/a	n/a	n/a	n/a	7.5	22
Novartis					Assay Description For MK2 inhibition, reactions contained compound or vehicle control, hsp27 peptide substrate and activated MK2 mix containing ATP. After incubation, ...				Bioorg Med Chem Lett 18: 6142-6 (2008) Article DOI: 10.1016/j.bmcl.2008.10.039 BindingDB Entry DOI: 10.7270/Q2V40SKW
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