Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'MAP kinase-activated protein kinase 2' and Ligand = 'BDBM30325'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM30325 (Pyrrolo-pyrimidone, 18) Show SMILES CCN(CC)Cc1ccc(C=Cc2cc(ccn2)-c2cc3c(nc[nH]c3=O)[nH]2)cc1 |w:10.9| Show InChI InChI=1S/C24H25N5O/c1-3-29(4-2)15-18-7-5-17(6-8-18)9-10-20-13-19(11-12-25-20)22-14-21-23(28-22)26-16-27-24(21)30/h5-14,16H,3-4,15H2,1-2H3,(H2,26,27,28,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	7.5	22
Novartis					Assay Description For MK2 inhibition, reactions contained compound or vehicle control, hsp27 peptide substrate and activated MK2 mix containing ATP. After incubation, ...				Bioorg Med Chem Lett 18: 6142-6 (2008) Article DOI: 10.1016/j.bmcl.2008.10.039 BindingDB Entry DOI: 10.7270/Q2V40SKW
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