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Found 1 hit Enz. Inhib. hit(s) with Target = 'Macrophage colony-stimulating factor 1 receptor' and Ligand = 'BDBM50255904'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255904
PNG
(CHEMBL4092632)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3CN(C(=O)N([C@H]4CCN(C4)C(=O)C(C)(C)C)c3n2)c2ccccc2Cl)cc1C |r|
Show InChI InChI=1S/C33H41ClN8O2/c1-22-18-24(10-11-27(22)39-16-14-38(5)15-17-39)36-31-35-19-23-20-41(28-9-7-6-8-26(28)34)32(44)42(29(23)37-31)25-12-13-40(21-25)30(43)33(2,3)4/h6-11,18-19,25H,12-17,20-21H2,1-5H3,(H,35,36,37)/t25-/m0/s1
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Article
PubMed
n/an/a 20n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair