Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Mast/stem cell growth factor receptor Kit [D816V]' and Ligand = 'BDBM369344'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM369344 (N-[1-[6-(2-methoxy-4-pyridyl)-7H- pyrrolo[2,3-d]py...) Show SMILES COc1cc(ccn1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1ccc(C)cc1 Show InChI InChI=1S/C24H26N6O3S/c1-16-3-5-19(6-4-16)34(31,32)29-18-8-11-30(12-9-18)24-20-14-21(28-23(20)26-15-27-24)17-7-10-25-22(13-17)33-2/h3-7,10,13-15,18,29H,8-9,11-12H2,1-2H3,(H,26,27,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Sapienza Universitàadi Roma					Assay Description The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...				J Med Chem 51: 1560-76 (2008) BindingDB Entry DOI: 10.7270/Q2HX1FZW
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