Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Mast/stem cell growth factor receptor Kit [D816V]' and Ligand = 'BDBM369352'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM369352 (N-[1-[6-(1,3-dimethylpyrazol-4-yl)-7H- pyrrolo[2,3...) Show SMILES Cc1nn(C)cc1-c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C23H24F3N7O3S/c1-14-19(12-32(2)30-14)20-11-18-21(29-20)27-13-28-22(18)33-9-7-15(8-10-33)31-37(34,35)17-5-3-16(4-6-17)36-23(24,25)26/h3-6,11-13,15,31H,7-10H2,1-2H3,(H,27,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Sapienza Universitàadi Roma					Assay Description The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...				J Med Chem 51: 1560-76 (2008) BindingDB Entry DOI: 10.7270/Q2HX1FZW
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