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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Mast/stem cell growth factor receptor Kit [V560G,D816V]' and Ligand = 'BDBM175559'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Mast/stem cell growth factor receptor Kit [V560G,D816V]


(Homo sapiens (Human))		BDBM175559
PNG
(US9688680, 111)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2ccc(cc2)C(C)(C)N)cc1
Show InChI InChI=1S/C27H30N6O/c1-18-4-6-19(7-5-18)13-29-26(34)22-14-32(15-22)25-24-12-21(16-33(24)31-17-30-25)20-8-10-23(11-9-20)27(2,3)28/h4-12,16-17,22H,13-15,28H2,1-3H3,(H,29,34)
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/a25



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
10,000 HMC1.2 cells were incubated in 22 ul culture media (phenol-red free IMDM, no serum) in each well of a 384-well plate and serum starved overnig...

US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair