Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Melanocortin receptor 5 (Homo sapiens (Human)) | BDBM50119368 ((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 860 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc. Curated by ChEMBL | Assay Description Displacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-5 receptor | Bioorg Med Chem Lett 14: 4417-23 (2004) Article DOI: 10.1016/j.bmcl.2004.06.059 BindingDB Entry DOI: 10.7270/Q2251HPH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melanocortin receptor 5 (Homo sapiens (Human)) | BDBM50119368 ((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 326 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Concentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC5R expressed in CHO cells | Bioorg Med Chem Lett 15: 3430-3 (2005) Article DOI: 10.1016/j.bmcl.2005.05.012 BindingDB Entry DOI: 10.7270/Q2959H2N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melanocortin receptor 5 (Homo sapiens (Human)) | BDBM50119368 ((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 326 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co. Curated by ChEMBL | Assay Description Evaluated for binding affinity against human melanocortin 5 (hMC5R) receptor by displacing [125I]-NDP-alpha-MSH radioligand expressed in CHO cells | J Med Chem 45: 4589-93 (2002) BindingDB Entry DOI: 10.7270/Q2GT5MH9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melanocortin receptor 5 (Homo sapiens (Human)) | BDBM50119368 ((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 326 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cells | Bioorg Med Chem Lett 16: 1130-3 (2006) Article DOI: 10.1016/j.bmcl.2005.11.095 BindingDB Entry DOI: 10.7270/Q2NG4Q5S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melanocortin receptor 5 (Rattus norvegicus) | BDBM50119368 ((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 1.58E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co. Curated by ChEMBL | Assay Description Evaluated for binding affinity against rat Melanocortin-5 receptor (rMC5R) by displacing [125I]NDP-alpha-MSH radioligand expressed in CHO cells | J Med Chem 45: 4589-93 (2002) BindingDB Entry DOI: 10.7270/Q2GT5MH9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melanocortin receptor 5 (Homo sapiens (Human)) | BDBM50119368 ((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | 737 | n/a | n/a | n/a | n/a |
Merck & Co. Curated by ChEMBL | Assay Description Functional activity as concentration at 50% maximum cAMP accumulation in human melanocortin 1 (MC5R) receptor | J Med Chem 45: 4589-93 (2002) BindingDB Entry DOI: 10.7270/Q2GT5MH9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melanocortin receptor 5 (Homo sapiens (Human)) | BDBM50119368 ((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | 736 | n/a | n/a | n/a | n/a |
Merck & Co. Curated by ChEMBL | Assay Description Evaluated for Functional Activity at MC5R as effective concentration at 50% maximum CMP accumulation | J Med Chem 45: 4589-93 (2002) BindingDB Entry DOI: 10.7270/Q2GT5MH9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melanocortin receptor 5 (Rattus norvegicus) | BDBM50119368 ((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | >3.00E+3 | n/a | n/a | n/a | n/a |
Merck & Co. Curated by ChEMBL | Assay Description Functional activity as concentration of the compound at 50% maximum cAMP accumulation in rat Melanocortin-5 receptor (rMC5R) | J Med Chem 45: 4589-93 (2002) BindingDB Entry DOI: 10.7270/Q2GT5MH9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melanocortin receptor 5 (Homo sapiens (Human)) | BDBM50119368 ((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 737 | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Activity against human MC5R by cAMP accumulation | Bioorg Med Chem Lett 16: 1130-3 (2006) Article DOI: 10.1016/j.bmcl.2005.11.095 BindingDB Entry DOI: 10.7270/Q2NG4Q5S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melanocortin receptor 5 (Homo sapiens (Human)) | BDBM50119368 ((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc. Curated by ChEMBL | Assay Description In vitro cAMP accumulation in HEK cells transfected with human Melanocortin 5 receptor (hMC5R) | Bioorg Med Chem Lett 13: 3793-6 (2003) BindingDB Entry DOI: 10.7270/Q2P26ZNW | |||||||||||
More data for this Ligand-Target Pair |