Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 2' and Ligand = 'BDBM252686'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM252686 (US9458176, 83) Show SMILES CCOc1cc(ccc1C(F)(F)F)-c1nc(c2CCO[C@H](C)Cn12)-c1ccnc(C)c1 |r| Show InChI InChI=1S/C23H24F3N3O2/c1-4-30-20-12-17(5-6-18(20)23(24,25)26)22-28-21(16-7-9-27-14(2)11-16)19-8-10-31-15(3)13-29(19)22/h5-7,9,11-12,15H,4,8,10,13H2,1-3H3/t15-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	25
Eisai R&D Management Co., Ltd. US Patent					Assay Description The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...				US Patent US9458176 (2016) BindingDB Entry DOI: 10.7270/Q2PK0F3D
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