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Found 1 hit Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 2' and Ligand = 'BDBM50169623'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM50169623
PNG
(CHEMBL3805718)
Show SMILES Cn1c2nc(ccc2n(CC(C)(C)C)c1=O)N1CC2CCC1CN2C(=O)c1ccccc1
Show InChI InChI=1S/C25H31N5O2/c1-25(2,3)16-30-20-12-13-21(26-22(20)27(4)24(30)32)28-14-19-11-10-18(28)15-29(19)23(31)17-8-6-5-7-9-17/h5-9,12-13,18-19H,10-11,14-16H2,1-4H3
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Article
PubMed
n/an/an/an/a 36n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant human mGlu2 receptor expressed in CHO cells assessed as potentiation of glutamate-induced effect preinc...

ACS Med Chem Lett 7: 312-7 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00459
BindingDB Entry DOI: 10.7270/Q2W95C3K
More data for this
Ligand-Target Pair