Compile Data Set for Download or QSAR

Found 4 hits Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 2' and Ligand = 'BDBM50332972'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50332972 (7-ethoxy-4-(3-(pyridin-4-yl)phenyl)-8-(trifluorome...) Show SMILES CCOc1cc2N=C(CC(=O)Nc2cc1C(F)(F)F)c1cccc(c1)-c1ccncc1 |c:6| Show InChI InChI=1S/C23H18F3N3O2/c1-2-31-21-12-20-19(11-17(21)23(24,25)26)29-22(30)13-18(28-20)16-5-3-4-15(10-16)14-6-8-27-9-7-14/h3-12H,2,13H2,1H3,(H,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Partial displacement of [3H]LY354740 from recombinant rat mGluR2				Bioorg Med Chem Lett 20: 6969-74 (2010) Article DOI: 10.1016/j.bmcl.2010.09.125 BindingDB Entry DOI: 10.7270/Q2X63N6R
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50332972 (7-ethoxy-4-(3-(pyridin-4-yl)phenyl)-8-(trifluorome...) Show SMILES CCOc1cc2N=C(CC(=O)Nc2cc1C(F)(F)F)c1cccc(c1)-c1ccncc1 |c:6| Show InChI InChI=1S/C23H18F3N3O2/c1-2-31-21-12-20-19(11-17(21)23(24,25)26)29-22(30)13-18(28-20)16-5-3-4-15(10-16)14-6-8-27-9-7-14/h3-12H,2,13H2,1H3,(H,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR2 receptor expressed in CHO cells assessed as inhibition of GIRK current				Bioorg Med Chem Lett 20: 6969-74 (2010) Article DOI: 10.1016/j.bmcl.2010.09.125 BindingDB Entry DOI: 10.7270/Q2X63N6R
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50332972 (7-ethoxy-4-(3-(pyridin-4-yl)phenyl)-8-(trifluorome...) Show SMILES CCOc1cc2N=C(CC(=O)Nc2cc1C(F)(F)F)c1cccc(c1)-c1ccncc1 |c:6| Show InChI InChI=1S/C23H18F3N3O2/c1-2-31-21-12-20-19(11-17(21)23(24,25)26)29-22(30)13-18(28-20)16-5-3-4-15(10-16)14-6-8-27-9-7-14/h3-12H,2,13H2,1H3,(H,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Antagonist activity at recombinant rat mGluR2 expressed in forskolin-stimulated CHO cells assessed as inhibition of (1S,3R)-ACPD induced cAMP product...				Bioorg Med Chem Lett 20: 6969-74 (2010) Article DOI: 10.1016/j.bmcl.2010.09.125 BindingDB Entry DOI: 10.7270/Q2X63N6R
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50332972 (7-ethoxy-4-(3-(pyridin-4-yl)phenyl)-8-(trifluorome...) Show SMILES CCOc1cc2N=C(CC(=O)Nc2cc1C(F)(F)F)c1cccc(c1)-c1ccncc1 |c:6| Show InChI InChI=1S/C23H18F3N3O2/c1-2-31-21-12-20-19(11-17(21)23(24,25)26)29-22(30)13-18(28-20)16-5-3-4-15(10-16)14-6-8-27-9-7-14/h3-12H,2,13H2,1H3,(H,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Antagonist activity at human mGluR2 receptor expressed in CHO cells assessed as inhibition of GIRK current				Bioorg Med Chem Lett 20: 6969-74 (2010) Article DOI: 10.1016/j.bmcl.2010.09.125 BindingDB Entry DOI: 10.7270/Q2X63N6R
					More data for this Ligand-Target Pair